HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Fluorobenzylcarbonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phthalic Acid | HCID 1017 | — |
| Reactant | HCID 178505759 | HCID 178505759 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(4-Fluorobenzylcarbonyl)benzoic acid | HCID 13799982 | — |
Reaction Steps
4-Fluorobenzyl magnesium chloride (4.6 g, 25 mmol) in ether is added to phthalic acid (7.4 g, 50 mmol) in ether. The reaction mixture is stirred under reflux for 2 hours, is cooled with ice and is hydrolysed with HCl to yield 2-(4-fluorobenzylcarbonyl)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180629B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-38b000fddabc47a08aa3ea485ef18d2d |
| Source note | uspto-grants-2001_01 |