Acetic Anhydride → HCID 17408507, compound

HRID 567785Notes

Reaction equation

HRID 567785 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>C(O)(=O)C>[C:17]([N:1]1[CH2:2][CH2:3][CH:4]([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:8]2=[O:16])[CH2:5][CH2:6]1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 886381,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one

Product 1

HCID 17408507HCID 17408507, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-piperidin-4-yl-1,3-dihydro-benzimidazol-2-one (0.2 g, 0.9 mmol) and acetic anhydride (0.2 ml, 2 mmol) was dissolved in acetic acid (5 ml) and stirred at room temperature for 30 minutes, then added water (10 ml) and evaporated to and oil. This was crystallized from ethanol (96%). Yield 0.18 g (0.7 mmol, 77 %). M.p. 212-214° C.

Workup

  1. customadded water (10 ml) and evaporated to and oil
  2. customThis was crystallized from ethanol (96%)

Sources & evidence

ORD record
ord-08d8be7cc6df4cb1bd05b2fb3e43b7c3
Source dataset
uspto-grants-2001_01
Patent number
US06180649B2

Reaction notes

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