HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate → Benzyl 2-[3-chloro-5-({[(2R)-1-isobutylpyrrolidinyl]methyl}amino)-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate | HCID 10663926 | — |
| Reactant | [(2R)-1-(2-methylpropyl)pyrrolidin-2-yl]methanamine | HCID 59900551 | — |
| Product | Benzyl 2-[3-chloro-5-({[(2R)-1-isobutylpyrrolidinyl]methyl}amino)-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate | HCID 59900523 | — |
Reaction Steps
The title compound was prepared by a similar method to preparation 42 from benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate (preperation 170 and [(2R)-1-isobutylpyrrolidinyl]methanamine [see preparation 60]. The crude product was purified by column chromatography on silica gel using ethyl acetate as the eluant, to afford the product as a yellow oil, (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180627B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-8e8e1f0704ca4fe08e8cbbfbdabf7b5e |
| Source note | uspto-grants-2001_01 |