tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylate → tert-Butyl (2S)-2-[({4-[2-(benzyloxy)-2-oxoethyl]-6-chloro-5-methyl-3-oxo-3,4-dihydro-2-pyrazinyl}amino)methyl]-1-pyrrolidinecarboxylate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylate	HCID 1512533	—
Reactant	Benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate	HCID 10663926	—
Product	tert-Butyl (2S)-2-[({4-[2-(benzyloxy)-2-oxoethyl]-6-chloro-5-methyl-3-oxo-3,4-dihydro-2-pyrazinyl}amino)methyl]-1-pyrrolidinecarboxylate	HCID 59900522	—

Reaction Steps

The title compound was prepared by a similar method to preparation 42 from benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate (preperation 17) and tert-butyl (2S)-2-(aminomethyl)-1-pyrrolidinecarboxylate [JP 63183560 A2], to afford the product as a colourless oil,(100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06180627B2
Source dataset	uspto-grants-2001_01
ORD ID	ord-bfc47b4cf9424248926910c575726b5a
Source note	uspto-grants-2001_01