HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (2R)-1-(cyclopropylmethyl)-2-piperidinecarboxamide | HCID 54480503 | — |
| Product | Ammonia | HCID 222 | — |
| Product | [(2R)-1-(Cyclopropylmethyl)piperidinyl]methylamine | HCID 59900487 | — |
Reaction Steps
The title compound was prepared by a similar method to preparation 60 from (2R)-1-(cyclopropylmethyl)-2-piperidinecarboxamide [see preparation 69] and lithium aluminum hydride. The crude product was purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (90:10:0.1) as the eluant, to afford the product as a yellow oil, (71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180627B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-8169bddc45784c8fa55602c3de4d1b9a |
| Source note | uspto-grants-2001_01 |