Pyridinium chloride → HCID 11042902, compound

HRID 567882Notes

Reaction equation

HRID 567882 reaction equation
C[O:2][C:3]1[C:18]([O:19]C)=[CH:17][C:6]2[C:7](=[O:16])[CH2:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[O:11][C:5]=2[CH:4]=1.Cl.N1C=CC=CC=1>O>[OH:2][C:3]1[C:18]([OH:19])=[CH:17][C:6]2[C:7](=[O:16])[CH2:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[O:11][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 11129367HCID 11129367, compound

Product 1

HCID 11042902HCID 11042902, compoundYield 66.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
190 °C

Procedure

A mixture of 7,8-dimethoxy-10,11-dihydrodibenz[b,f]oxepin-10-one (5 mg) and pyridine hydrochloride (20 mg) was heated at 190° C. for two hours. Water was added to the reaction mixture followed by extracting with ethyl acetate. This was washed with water and dried over magnesium sulfate and the solvent was evaporated to give the title compound (Compound 13) (3 mg, 60%) as brown plates.

Workup

  1. extractionby extracting with ethyl acetate
  2. washThis was washed with water
  3. dry with materialdried over magnesium sulfate
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-1314476f631b40ef8e6b59f0441cc039
Source dataset
uspto-grants-2001_01
Patent number
US06180659B2

Reaction notes

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