Methanol--water (1/1) → Sampatrilat

Participants

Reaction Steps

A solution of (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (3.0 g) in a 1:5 water/methanol mixture (18 ml) or a 1:10 water/acetone mixture (33 ml) was stirred for 3 days at room temperature. The resulting solid was collected by filtration and dried to give the title compound as a white solid, m.p. 246-8° C. (from the aqueous methanol method), m.p. 242-3° C. (from the aqueous acetone method).

Provenance & Evidence