HCID 86756334, compound → Sampatrilat

Participants

Reaction Steps

(S,S,S)-N-(1-[2-Carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (847.0 g) was dissolved in water (762 ml) and the solution diluted with acetone (1.0 l). This solution was added slowly to vigorously stirred acetone (18.05 l) at room temperature and a white solid precipitated. The mixture was stirred at room temperature for 18 hours, the solid was collected by filtration, washed with acetone and dried to give the title compound as a white solid (775 g), m.p. 179-181° C. Found: C,53.42; H,6.88; N,9.37; S,5.49. C26H40N4O9S requires: C,53.41; H,6.90; N,9.58; S,5.48%.

Provenance & Evidence