HCID 86756335, compound → HCID 86756337, compound

Participants

Reaction Steps

To a solution of tert-butyl (S,S,S)-N-(1-[3-(N6-benzyloxycarbonyl-N2-mesyllysylamino)-2-(tert-butoxycarbonyl)propyl]-1-cyclopentylcarbonyl)-O4-tert-butyltyrosinate (48.64 g, 54.8 mmmol) in industrial methylated spirits (1.0 L) was added 5% palladium-on-carbon (5 g) (water wet) and the mixture was hydrogenated at 345-414 kPa (50-60 psi) and at room temperature for 19 hours. After removal of the catalyst by filtration, the resulting solution was concentrated under reduced pressure to provide the title compound as a colourless oil (46.56 g) which contained ethanol.

Provenance & Evidence