HCID 9849876, compound → HCID 21262826, compound

Participants

Reaction Steps

To a solution of 4-{2-[3,4-bis(difluoromethoxy)phenyl]-2-[6-(4-nitrophenoxy)-3-pyridyl]ethyl}pyridine (600 mg, 1.13 mmol) from Example 6, Step 5 in 20 mL EtOH, was added 120 mg of Pd/C 10% and the resulting mixture was stirred 20 h under H2 atmosphere. The reaction was filtered on celite, washed with ethyl acetate and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (10% EtOH/Ethyl acetate) to afford the amine as an oil (500 mg, 88%).

Provenance & Evidence