Hydrochloric Acid → Cryptophycin 55

Participants

Reaction Steps

To a solution of Cryptophycin 52 (6 mg) in 0.6 mL of 2:1 1,2-dimethoxyethane/water was added 2 uL of 12 N HCl. The solution was allowed to stir at room temperature for 20 hours, neutralized with potassium carbonate, filtered through a 5 m filter, and evaporated. The acetonitrile-soluble material was purified by reversed-phase HPLC on C18 using 4:1 MeOH/water to obtain 3.0 mg of Cryptophycin 55 (48%). The product was characterized using NMR.

Provenance & Evidence