Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-isocyanato-2-methoxy- → CXCR2 antagonist 8
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 반응물 | 2-Amino-5-Nitrophenol | HCID 4984721 | — |
| 생성물 | CXCR2 antagonist 8 | HCID 9796445 | 27% |
반응 단계
N-(2-Hydroxy-4-nitrophenyl)-N′-(2-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 2-methoxyphenylisocyanate(1 mmol.) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (82 mg, 27%). EI-MS m/z 302(M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06180675B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-5e529a6bacf64ef1b28402f246b73c7a |
| 출처 메모 | uspto-grants-2001_01 |