HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromophenyl isocyanate → N-(2-hydroxy 4-trifluoromethylphenyl) N'-(2-bromophenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromophenyl isocyanate | HCID 137097 | — |
| Reactant | 2-Amino-5-(trifluoromethyl)phenol | HCID 15524277 | — |
| Product | N-(2-hydroxy 4-trifluoromethylphenyl) N'-(2-bromophenyl)urea | HCID 22011349 | 66.6% |
Reaction Steps
The urea was prepared from 2-hydroxy 4-trifluoromethyl aniline(example 7a, 0.171 g, 1 mmol) and 2-bromophenylisocyanate(1 mmol) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the desired compound(0.25 g, 54%). EI-MS m/z 375(M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180675B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-4334df09704a47509a450caca739af20 |
| Source note | uspto-grants-2001_01 |