2-Bromophenyl isocyanate → HCID 22011327, compound

HRID 568018Notes

Reaction equation

HRID 568018 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[NH:21]C2C=CC=CC=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[Br:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[N:35]=[C:36]=[O:37]>>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[NH:21][C:36]([NH:35][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[Br:28])=[O:37])(=[O:13])=[O:12])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 1370972-Bromophenyl isocyanateHCID 54436784HCID 54436784, compound

Product 1

HCID 22011327HCID 22011327, compoundYield 24%

Procedure

The urea was synthesized from 2-[(4-acetamidophenyl)sulfonylamino]phenyl aniline(1 mmol) and 2-bromophenylisocyanate(1 mmol) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the desired compound(0.12 g, 24%). EI-MS mn/z 501(M−H)−.

Workup

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane
  2. filtrationFiltering

Sources & evidence

ORD record
ord-e4ab7a6a567c46f2821ff06b2940b41b
Source dataset
uspto-grants-2001_01
Patent number
US06180675B2

Reaction notes

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