2-Bromophenyl isocyanate → (2-Bromophenyl)urea

HRID 568019Notes

Reaction equation

HRID 568019 reaction equation
S1C=CC=C1S([NH:9]C1C=CC=CC=1N)(=O)=O.[Br:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]=[C:25]=[O:26]>>[Br:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH:24][C:25](=[O:26])[NH2:9]

Participants

3

Reactant 2

HCID 1370972-Bromophenyl isocyanateHCID 2310676N-(2-aminophenyl)thiophene-2-sulfonamide

Product 1

HCID 139386(2-Bromophenyl)ureaYield 134.9%

Procedure

The urea was synthesized from 2-(2-thiophenesulfonylamino) aniline(1 mmol) and 2-bromophenylisocyanate(1 mmol) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the desired compound(0.29 g, 64%). EI-MS m/z 450(M−H)−.

Workup

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane
  2. filtrationFiltering

Sources & evidence

ORD record
ord-e6c156b927a740b29fa14419a8857add
Source dataset
uspto-grants-2001_01
Patent number
US06180675B2

Reaction notes

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