HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → HCID 117622757, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Benzoic acid, 4-amino-, 1,1-dimethylethyl ester | HCID 233272 | — |
| Reactant | HCID 117622589 | HCID 117622589 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 117622757 | HCID 117622757 | — |
Reaction Steps
95.0 mg (246 μmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-(1-methylcyclopropyl)propanoic acid (racemate), 47.5 mg (246 μmol) of tert-butyl 4-aminobenzoate, 34.9 mg (246 μmol) of Oxima and 38.3 μl (246 μmol) of DIC in 2.5 ml of dimethylformamide were reacted according to General Method 5B. Yield: 101 mg (66% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-4c8d866b4826420ea6abbec0927d5349 |
| Source note | uspto-grants-2016_09 |