N-bromobutanimide → 5-Bromo-3-(4-pyridyl)-2-(3-trifluoromethylphenyl)indole

HRID 568173Notes

Reaction equation

HRID 568173 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[CH:3][CH:2]=1.C1C(=O)N([Br:33])C(=O)C1.NC1N=C2C(C(C3C=CN=CC=3)=C(C3C=CC(F)=CC=3)N2)=CC=1Br>>[Br:33][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=1)=[C:7]2[C:4]1[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 67184N-bromobutanimideHCID 181751903-(4-Pyridyl)-2-(3-trifluoromethylphenyl)indoleHCID 18175227HCID 18175227, compound

Product 1

HCID 181752505-Bromo-3-(4-pyridyl)-2-(3-trifluoromethylphenyl)indole

Procedure

3-(4-Pyridyl)-2-(3-trifluoromethylphenyl)indole was treated with NBS in the same manner as 6-amino-5-bromo-3-(4-pyridyl)-2-(4-fluorophenyl)-7-aza-indole to afford the title compound: Mass Spectrum (CI) 417 (MBr81-H).

Sources & evidence

ORD record
ord-e16189bcda3e46d28c3ab8533120b261
Source dataset
uspto-grants-2001_01
Patent number
US06180643B2

Reaction notes

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