참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | ethyl 4,6-dichloro-1H-indole-2-carboxylate | HCID 2736407 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate | HCID 2794948 | — |
반응 단계
Combine 2-carboethoxy-4,6-dichloroindole (10.0 g, 0.039 mol), and dimethylformamide (4.5 mL, 0.057 mol) in dichloroethane (20 mL). Add phosphoryl chloride (8.9 g, 0.058 mmol). Heat to 80° C. After 18 hours, cool the reaction mixture to ambient temperature and combine with aqueous 1 M sodium acetate solution and stir. After 18 hours, filter, rinse with water, and dry to give 3-formyl-2-carboethoxy-4,6-dichloroindole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06180786B2 |
|---|
| 출처 데이터셋 | uspto-grants-2001_01 |
|---|
| ORD ID | ord-e8efce8ed6ef48ca829ab6cf28d56553 |
|---|
| 출처 메모 | uspto-grants-2001_01 |
|---|
