Methyl iodide → HCID 178459471, compound

Participants

Reaction Steps

Iodomethane (0.6 ml) is added to 54.0 mg of allyl (1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-[1-hydroxy-1-(imidazo[5,1-b]thiazol-2-yl)methyl]pyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate (stereoisomer A) described in Example 16-a), and the mixture is stirred in an argon atmosphere in a light-shielded state at room temperature for 5 hr. The excess reagent is removed by evaporation under reduced pressure to give 68.9 mg of allyl(1R,5S,6S)-6-((1R)-1-hydroxyethyl)-2-[(3S,5S)-1-allyloxycarbonyl-5-[1-hydroxy-1-(6-methylimidazo[5,1-b]thiazolium-2-yl)methyl]pyrrolidin-3-yl]thio-1-methylcarbapen-2-em-3-carboxylate iodide (stereoisomer A) as a slightly yellow amorphous material.

Provenance & Evidence