huagongshe.com
HRID568246

反应详情

EQUATION

反应方程式

HRID 568246 的结构方程式

REACTANTS

反应物

2
结构：C=CCOC(=O)C1=C(OP(=O)(Oc2ccccc2)Oc2ccccc2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12
HCID11167930

未命名化合物

结构：C=CCOC(=O)N1C[C@@H](SC(C)=O)C[C@H]1Cc1cn2c(C)ncc2s1
HCID88217089

未命名化合物

PRODUCTS

生成物

1
结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3cn4c(C)ncc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12
HCID131722343

未命名化合物

收率 53.5%

PROCEDURE

实验过程

The procedure of Example 23-a) is repeated to prepare 653.0 mg of a mercaptan compound as a yellow oil from 766.4 mg of (3S,5S)-3-acetylthio-1-allyloxycarbonyl-5-(5-methylimidazo[5,1-b]thiazol-2-yl)methylpyrrolidine described in Synthesis Example 11. Allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-(5-methylimidazo[5,1-b]thiazol-2-yl)methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate (560.2 mg) is prepared as a colorless amorphous material from this mercaptan and 891.6 mg of allyl(1R,5R,6S)-2-(diphenylphosphono)oxy-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate.

WORKUP

后处理

  1. customdescribed in Synthesis Example 11