Methyl iodide → HCID 131722344, compound

Participants

Reaction Steps

Iodomethane (0.468 ml) is added to 43.0 mg of allyl (1R,5S,6S)-2-[(3S,5R)-1-allyloxycarbonyl-5-(imidazo[5,1-b]thiazol-7-yl)methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate described in Example 34-a), and the mixture is stirred in an argon atmosphere in a light-shielded state at room temperature for 19 hr. The excess reagent is removed by evaporation under reduced pressure to give a crude product of allyl(1R,5S,6S)-2-[(3S,5R)-1-allyloxycarbonyl-5-(6-methylimidazo[5,1-b]thiazolium-7-yl)methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate iodide. The procedure of Example 11-b) is repeated, except that the whole quantity of the crude product prepared just above is used. Thus, 3.2 mg of the title compound is obtained.

Provenance & Evidence