Triphenylphosphine → HCID 21262400, compound

Participants

Reaction Conditions

Reaction Steps

Triphenylphosphine (2.51 g) is added to a solution of 1.23 g of 5-hydroxymethylimidazo[5,1-b]thiazole hydrochloride in 20 ml of DMF, and the mixture is stirred at 100° C. for 12 hr. The solvent is removed by evaporation, and the residue is purified by column chromatography on silica gel (methanol:dichloromethane=5:95) to give 2.1 g of (imidazo[5,1-b]thiazol-5-yl)methyltriphenylphosphonium chloride.

Provenance & Evidence