Thionyl Chloride → HCID 21262359, compound

Participants

Reaction Conditions

Reaction Steps

3-Hydroxymethyl-5-methylimidazo[5,1-b]thiazolehydrochloride (1.10 g) is suspended in 20 ml of THF, 0.7 ml of thionyl chloride is added thereto, and the mixture is stirred at 85° C. for 3.5 hr. The solvent is removed by evaporation to give 1.10 g of 3-chloromethyl-5-methylimidazo[5,1-b]thiazolehydrochloride. This compound is dissolved in 7 ml of DMF, 1.36 g of triphenylphosphine is added thereto, and the mixture is stirred at 83° C. for 15 hr and at 90° C. for 4 hr. The resultant precipitate is collected by filtration and washed with diethyl ether to give 1.87 g of (5-methylimidazo[5,1-b]thiazol-3-yl)methyltriphenylphosphonium chloride hydrochloride.

Provenance & Evidence