Pyridine → HCID 53875308, compound

Participants

Reaction Steps

Three point five grams of 4-(4'-hydroxyphenyl)benzoic acid were dispersed in a mixed solvent of 30 ml of carbon tetrachloride and 5 ml of pyridine and then heated. 2.5 ml of (s)-2-chloro-3-methylbutanic acid chloride was dropped into the mixed solution with refluxing for 3 hours. After removing the solvent, a small amount of water was added to decompose unreacted nonanic acid chloride. (s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid (H) after washing the residue with methanol. 5 ml of thionylchloride was reacted with the compound (H) dispersed in 20 ml of carbon tetrachloride to obtain 6.5 g of (s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid chloride (I).

Provenance & Evidence