HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 20150338, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 384484 | HCID 384484 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Piperidine | HCID 8082 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 20150338 | HCID 20150338 | — |
Reaction Steps
The procedure is as in Example 1, but starting with (2-phenyl-4-quinolyl)oxyacetic acid (3 g), thionyl chloride (2.35 cc) in chloroform (50 cc), piperidine (1.04 cc) and triethylamine (3 cc) in toluene (50 cc). The residue obtained is converted in acetone to its hydrochloride by adding a solution of hydrochloric acid in ethyl ether. After recrystallization in ethanol, 1-[(2-phenyl-4-quinolyl)oxyacetyl]piperidine hydrochloride (0.46 g), m.p. 146° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728647 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-70f1218acf0a48aebd428af8437b479f |
| Source note | uspto-grants-1988_03 |