Methanesulfonyl chloride → HCID 20150454, compound

Participants

Reaction Steps

Methanesulphonyl chloride (0.15 cm3) was added dropwise to a stirred solution of 8-methyl-6-(4-aminophenyl)-2-(1H)-quinolone (0.47 g) (see Example 13) in pyridine (3 cm3) at room temperature. After 0.5 hours volatile material was removed in in vacuo and the residue was partitioned between water (50 cm3) and dichloromethane:methanol, 4:1 (50 cm3). The insoluble material was filtered off, washed with methanol (10 cm3) and dried to afford the title compound, m.p. 340°-343° (0.45 g).

Provenance & Evidence