反应详情

To the crude product composed by ethyl N-[2-[[[2-[(aminoimino-methyl)amino]-4-thiazolyl]methyl]thio]ethyl]formimidate, 5.6 g of p-toluensulfonamide in 50 ml of methanol are dropwise added under stirring and at room temperature. The mixture is kept under stirring for 1 hour at room temperature, the solvent is removed by distillation under reduced pressure, and the obtained residue is purified by 60-silicagel column chromatography. 9.8 g of N-toluen-sulphonyl-N'-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]formamidine are obtained, having the same physico-chemical properties as in Example 1.

1. additionare dropwise added
2. stirringunder stirring for 1 hour at room temperature
3. customthe solvent is removed by distillation under reduced pressure
4. customthe obtained residue is purified by 60-silicagel column chromatography