Methanesulfonic Acid → Nanterinone mesylate

Participants

Reaction Steps

A stirred solution of 8-methyl-6-(2,4-dimethylimidazol-1-yl)-2-(1H)-quinolone (365.7 g) in methanol (914 cm3) at 60° was treated with methanesulphonic acid (141.9 g) over 5 minutes. Ethyl acetate (3.4 l) was added and the solution was allowed to cool to room temperature for 1 hour followed by cooling in an ice bath for 2 hours. The solid was filtered off, washed with ethyl acetate (450 cm3) and dried in vacuo at 50° to afford the title compound, m.p. 282°-284°.

Provenance & Evidence