Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 6-Bromo-8-methylquinolin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide | HCID 14221021 | — |
| 생성물 | 6-Bromo-8-methylquinolin-2(1H)-one | HCID 13836183 | — |
반응 단계
Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide (2.0 g) was added portionwise with stirring to 98% sulphuric acid (15 cm3) at room temperature. After 16 hours the solution was poured onto ice (100 cm3) and the resulting precipitate was filtered off and dried (1.5 g). Recrystallisation from ethyl acetate-methanol afforded 6-bromo-8-methyl-2-(1H)-quinolone, m.p. 272°-274°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04728653 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-6044856d9abf4673b1648f563919d97b |
| 출처 메모 | uspto-grants-1988_03 |