Water → HCID 13604804, compound

HRID 568400Notes

Reaction equation

HRID 568400 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([O-:11])([O-])=O.[Na+].[Na+].[OH2:14]>ClCCl>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:8]([C:6]1[CH:5]=[CH:4][N+:3]([O-:14])=[CH:2][CH:7]=1)=[O:11]

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 104392-Aminopyridine

Product 1

HCID 13604804HCID 13604804, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred suspension of the acid chloride in dichloromethane (50ml) at 0° was treated with 2-aminopyridine (1.823 g, 19.4 mmol), warmed to room temperature. After 3 hours the mixture was evaporated in vacuo to give a solid. The solid was dissolved in water (100 ml) and the solution basified with saturated aq. Na2CO3 solution. The precipitate was filtered and recrystallised from water to give the title compound as a three quarter hydrate (1.274 g), m.p. 232°-233° .

Workup

  1. customAfter 3 hours the mixture was evaporated in vacuo
  2. customto give a solid
  3. filtrationThe precipitate was filtered
  4. customrecrystallised from water

Sources & evidence

ORD record
ord-d591ff8b069e44a19e4fdb5a24a4add3
Source dataset
uspto-grants-1988_03
Patent number
US04728658

Reaction notes

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