Pyridinium hydrobromide → 4-[5-Chloro-2-(difluoromethoxy)phenyl]-5-methoxypyridin-2(1H)-one

HRID 56844Notes

Reaction equation

HRID 56844 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH:19]([F:21])[F:20])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]=[C:10]([O:16]C)[CH:9]=2)[CH:7]=1.Br.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH:19]([F:21])[F:20])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][NH:11][C:10](=[O:16])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 21226041Pyridinium hydrobromideHCID 1176049044-[5-Chloro-2-(difluoromethoxy)phenyl]-2,5-dimethoxypyridine

Product 1

HCID 1176228824-[5-Chloro-2-(difluoromethoxy)phenyl]-5-methoxypyridin-2(1H)-one

Procedure

170 mg (purity 90%, 0.49 mmol) of 4-[5-chloro-2-(difluoromethoxy)phenyl]-2,5-dimethoxypyridine and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 127 mg (87% of theory)

Sources & evidence

ORD record
ord-05f87568bc0245d6a91f81b9f62d23bc
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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