1-(2-Hydroxyethyl)piperazine → HCID 12817107, compound

HRID 568475Notes

Reaction equation

HRID 568475 reaction equation
[CH2:1]([NH:8][C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>O1CCOCC1>[CH2:1]([NH:8][C:9]1[C:14]2[N:15]=[C:16]([N:32]3[CH2:33][CH2:34][N:29]([CH2:28][CH2:27][OH:26])[CH2:30][CH2:31]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 12817010HCID 12817010, compound

Product 1

HCID 12817107HCID 12817107, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This compound was prepared analogous to Example 118 from 8-benzylamino-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 139°-141° C.) and N-hydroxyethyl-piperazine in dioxane at 70° C.

Sources & evidence

ORD record
ord-c49a59ce01a643fc92d7bb381193857d
Source dataset
uspto-grants-1988_03
Patent number
US04728646

Reaction notes

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