Diketene → HCID 20150258, compound

HRID 568482Notes

Reaction equation

HRID 568482 reaction equation
[CH2:1]([NH:8][C:9]1[C:14]2[N:15]=[C:16]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22](=[O:25])[CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:32]=[C:33]1[O:37][C:35](=[O:36])[CH2:34]1>CC(C)=O>[C:35]([N:29]1[CH2:28][CH2:27][N:26]([C:16]2[N:17]=[C:18]([N:19]3[CH2:20][CH2:21][S:22](=[O:25])[CH2:23][CH2:24]3)[C:13]3[N:12]=[CH:11][N:10]=[C:9]([NH:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:14]=3[N:15]=2)[CH2:31][CH2:30]1)(=[O:36])[CH2:34][C:33]([CH3:32])=[O:37]

Participants

4

Reactant 2

HCID 12661DiketeneHCID 3061031Pyrimido(5,4-d)pyrimidin-4-amine, N-(phenylmethyl)-6-(1-piperazinyl)-8-(4-thiomorpholinyl)-, S-oxide

Product 1

HCID 20150258HCID 20150258, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

This compound was prepared analogous to Example 5 from 8-benzylamino-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido-[5,4-d]-pyrimidine and diketene in acetone under reflux.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-0a32d3473aeb4d1ba70023162be76730
Source dataset
uspto-grants-1988_03
Patent number
US04728646

Reaction notes

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