反应详情

温度

-10 °C

A mixture of 5.0 g of (E)-4-(1H-imidazol-1-yl)-2-butenamine, 11.5 g of 2-(methylthio)benz[cd]indole hydroiodide and 400 ml of ethanol was stirred and heated at reflux for 16 hours, then clarified while hot. The filtrate was concentrated to 250 ml, cooled to -10° C. and the resulting solid collected, washed with ethanol, ether and dried at 60° C. in vacuo, giving 9.3 g of the desired product, mp 152°-155° C. (dec.).

1. temperatureheated
2. temperatureat reflux for 16 hours
3. concentrationThe filtrate was concentrated to 250 ml
4. customthe resulting solid collected
5. washwashed with ethanol, ether
6. customdried at 60° C. in vacuo