N-[3-(1H-imidazol-1-yl)propyl]glycinamide → HCID 178521282, compound

HRID 568493Notes

Reaction equation

HRID 568493 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10](=[O:13])[CH2:11][NH2:12])[CH:5]=[CH:4][N:3]=[CH:2]1.I.CS[C:17]1[C:25]2[CH:26]=[CH:27][CH:28]=[C:23]3[C:24]=2[C:19](=[CH:20][CH:21]=[CH:22]3)[N:18]=1>C(O)C>[N:18]1[C:19]2[C:24]3[C:23](=[CH:28][CH:27]=[CH:26][C:25]=3[C:17]=1[NH:12][CH2:11][C:10]([NH:9][CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)=[O:13])[CH:22]=[CH:21][CH:20]=2

Participants

4

Reactant 2

HCID 19914592N-[3-(1H-imidazol-1-yl)propyl]glycinamideHCID 201506502-Methylthiobenz(cd)indole hydriodide

Product 1

HCID 178521282HCID 178521282, compoundYield 43.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.7 g of N-[3-(1H-imidazol-1-yl)propyl]glycinamide, 425 ml of ethanol, and 5.0 g of 2-(methylthio)benz[cd]indole hydroiodide was reacted as described in Example 19, giving 2.2 g of the desired product, mp 145°-146° C.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c3eaacd6bcc14b6b99183350231a8ca5
Source dataset
uspto-grants-1988_03
Patent number
US04728663

Reaction notes

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