HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-cyanophenylboronic acid → 4-Chloro-2-(5-ethoxy-2-methoxypyridin-4-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-cyanophenylboronic acid | HCID 46738934 | — |
| Reactant | 5-Ethoxy-4-iodo-2-methoxypyridine | HCID 117605486 | — |
| Product | 4-Chloro-2-(5-ethoxy-2-methoxypyridin-4-yl)benzonitrile | HCID 117604968 | — |
Reaction Steps
322 mg (purity 93%, 1.07 mmol) of 5-ethoxy-4-iodo-2-methoxypyridine and 234 mg (1.29 mmol, 1.2 eq.) of 5-chloro-2-cyanophenylboronic acid in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. The crude product was purified by flash chromatography (silica gel 50, cyclohexane/ethyl acetate gradient). Yield: 135 mg (41% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-92844939f5a14b539b19f8cf2c1cf435 |
| Source note | uspto-grants-2016_09 |