Pyridinium hydrobromide → 4-Chloro-2-(5-ethoxy-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

HRID 56852Notes

Reaction equation

HRID 56852 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([O:16][CH2:17][CH3:18])=[CH:14][N:13]=[C:12]([O:19]C)[CH:11]=2)[CH:3]=1.Br.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([O:16][CH2:17][CH3:18])=[CH:14][NH:13][C:12](=[O:19])[CH:11]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 21226041Pyridinium hydrobromideHCID 1176049684-Chloro-2-(5-ethoxy-2-methoxypyridin-4-yl)benzonitrile

Product 1

HCID 1176054644-Chloro-2-(5-ethoxy-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

Procedure

135 mg (0.44 mmol) of 4-chloro-2-(5-ethoxy-2-methoxypyridin-4-yl)benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 134 mg (purity 76%, 83% of theory)

Sources & evidence

ORD record
ord-586c77b3457b4c84a14357ce1c991451
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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