HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridinium hydrobromide → 4-Chloro-2-[5-(difluoromethoxy)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridinium hydrobromide | HCID 21226041 | — |
| Edukt | 4-Chloro-2-[5-(difluoromethoxy)-2-methoxypyridin-4-yl]benzonitrile | HCID 117605724 | — |
| Produkt | 4-Chloro-2-[5-(difluoromethoxy)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile | HCID 117605696 | — |
Reaktionsschritte
230 mg (purity 80%, 0.59 mmol) of 4-chloro-2-[5-(difluoromethoxy)-2-methoxypyridin-4-yl]benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. The crude product was purified by flash chromatography (IR-50SI, dichloromethane/methanol 3-25%). Yield: 167 mg (95% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434690B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-ded25a1437784d6fafb707e5b36c77fc |
| Quellennotiz | uspto-grants-2016_09 |