Sodium methanolate methanol → HCID 178510665, compound

Participants

Reaction Steps

To a mixture of 6.921 g of 4-cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazolium-5-olate and 50 ml of dry methanol was added 20.37 g of 25% (W/W) sodium methoxide methanol solution under ice-cooling. The reaction mixture was stirred for ten minutes at the same temperature and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography on reversed phase silica gel [Merck RP-8 eluted with 1% acetic acid solution] to give 4.21 g of 4-cyano-1-β-D-ribofuranosylimidazolium-5-olate.

Provenance & Evidence