2,3-Dichloroanisole → 2,3-Dichloro-4-methoxy-2',3'-dimethylbenzophenone

HRID 568638Notes

Reaction equation

HRID 568638 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[O:20][CH3:21].[Al+3].[Cl-].[Cl-].[Cl-]>>[Cl:19][C:18]1[C:13]([Cl:12])=[C:14]([O:20][CH3:21])[CH:15]=[CH:16][C:17]=1[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[C:2]=1[CH3:1])=[O:5]

Participants

4

Reactant 3

HCID 161262,3-DichloroanisoleHCID 28008992,3-Dimethylbenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 201505222,3-Dichloro-4-methoxy-2',3'-dimethylbenzophenone

Procedure

The Friedel-Crafts procedure of Example 24a is repeated with 33.7 g of 2,3-dimethylbenzoyl chloride, 54 g of 2,3-dichloroanisole and 26.7 AlCl3 being reacted to form 2,3-dichloro-4-methoxy-2',3'-dimethylbenzophenone.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-be1c48a56c7a4592a8feb930ba554dd9
Source dataset
uspto-grants-1988_03
Patent number
US04728662

Reaction notes

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