HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 13015692, compound → HCID 135589642, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 13015692 | HCID 13015692 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 135589642 | HCID 135589642 | — |
Reaction Steps
7-chloro-6-methoxy-3-(2-pyridyl)-1,2-benzisoxazole (24.4 g) is refluxed for 1.5 hours in 450 ml of 48% HBr. The precipitated hydrobromide salt is filtered off, washed with ether and neutralized with 10% NaHCO3 solution. The free base is filtered off and dried, giving 7-chloro-6-hydroxy-3-(2-pyridyl)-1,2-benzisoxazole, mp 209°-211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-7bdc9c71ca714645a20063666e3f4dd3 |
| Source note | uspto-grants-1988_03 |