Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Dimethoxybenzene | HCID 9025 | — |
| Reactant | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 13015735 | HCID 13015735 | — |
Reaction Steps
m-dimethoxybenzene (27.6 g) and o-fluorobenzoyl chloride (31.7 g) are dissolved in 200 ml of dichloroethane and AlCl3 (28.0 g) is added portionwise. After two hours an additional 56 g of AlCl3 is added and the reaction mixture warmed at 60° C. for 1.5 hours. It is then poured into H2O and extracted with ethylacetate. Drying and evaporation gives a crystalline compound. Trituration with toluene gives 2,4-dihydroxy-2'-fluorobenzophenone, mp 109°-111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04728662 |
|---|
| Source dataset | uspto-grants-1988_03 |
|---|
| ORD ID | ord-c42a964cfa484069908f5c0fe6abb914 |
|---|
| Source note | uspto-grants-1988_03 |
|---|
