HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → [(E)-[(2-fluorophenyl)-(2-hydroxy-4-methoxy-3-methylphenyl)methylidene]amino] acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 6-[(E)-C-(2-fluorophenyl)-N-hydroxycarbonimidoyl]-3-methoxy-2-methylphenol | HCID 136477380 | — |
| Product | [(E)-[(2-fluorophenyl)-(2-hydroxy-4-methoxy-3-methylphenyl)methylidene]amino] acetate | HCID 136477425 | — |
Reaction Steps
E-2'-fluoro-2-hydroxy-4-methoxy-3-methylbenzophenone oxime (20.0 g) is warmed on a steam bath for one hour with 12 ml of acetic anhydride. The acetic anhydride is evaporated in vacuo and the product is distributed between ether and H2O, then the ether is washed with 10% NaHCO3. Evaporation and trituration of the crystalline product with hexane gives E-2'-fluoro-2-hydroxy-4-methoxy-3-methylbenzophenone O-acetyl oxime, mp 83°-86° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-2e8b5378bfc5468e9c3eb536d0f619c3 |
| Source note | uspto-grants-1988_03 |