HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 3-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 3-(2-Fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole | HCID 13015728 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole | HCID 135589643 | — |
Reaction Steps
3-(2-fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole (16.1 g) is heated at 200° C. for two hours with 64 g of pyridine hydrochloride. The melt is poured into H2O and extracted with ethyl acetate. After washing with 5% HCl the ethyl acetate is dried and evaporated to give 3-(2-fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole, mp 216°-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-1d1ab942513043c497b432d2e93cd102 |
| Source note | uspto-grants-1988_03 |