HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 135589636, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 13015746 | HCID 13015746 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 135589636 | HCID 135589636 | — |
Reaction Steps
3-(2-fluorophenyl)-7-iodo-6-methoxy-1,2-benzisoxazole (8.2 g) is refluxed 18 hours in 130 ml of CH2Cl2 containing 6.6 ml of BBr3. The reaction mixture is poured into H2O and extracted into ether. Drying and evaporation gives a crystalline product that is triturated well with hexane to yield 3-(2-fluorophenyl)-6-hydroxy-7-iodo-1,2-benzisoxazole, mp 212°-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-36a6476999b44f37a72c04dc31c9aa36 |
| Source note | uspto-grants-1988_03 |