Ethyl bromoacetate → HCID 13015773, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-fluorophenyl)-6-hydroxy-7-iodo-1,2-benzisoxazole (7.80 g) in 80 ml of DMF is treated at 60° C. with 6.6 g of K2CO3 and 7.9 g of ethyl bromoacetate. After one hour the temperature is increased to 90° C. and 80 ml of H2O and 8 ml of 50% NaOH are added. After an additional 30 minutes the mixture is poured into H2O and acidified and then extracted into ether, dried and evaporated to yield {[3-(2-fluorophenyl)-7-iodo-1,2-benzisoxazol-6-yl]oxy}acetic acid, mp 178°-180° C.

Provenance & Evidence