HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 568662Generated: October 31, 2026
Acetic Anhydride → [(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2,3-difluorophenyl)methylidene]amino] acetate
https://huagongshe.com/reaction/568662
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-chloro-6-[(E)-C-(2,3-difluorophenyl)-N-hydroxycarbonimidoyl]-3-methoxyphenol | HCID 136477389 | — |
| Product | [(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2,3-difluorophenyl)methylidene]amino] acetate | HCID 136477386 | — |
Reaction Steps
A mixture of 1.5 g of E-3-chloro-2',3'-difluoro-2-hydroxy-4-methoxybenzophenone oxime and 0.67 g of acetic anhydride are warmed at 60° C. for 30 minutes. The mixture is dissolved and then solidifies. The residue is partitioned between ethyl acetate and 10% NaHCO3. The ethyl acetate extract is washed, dried over Na2SO4 and evaporated to give E-3-chloro-2',3'-difluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime, mp 136°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04728662 |
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| Source dataset | uspto-grants-1988_03 |
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| ORD ID | ord-14e43cea24394faea139597eb1923e7e |
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| Source note | uspto-grants-1988_03 |
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