Ethyl bromoacetate → HCID 13015760, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 12 g of 7-chloro-6-hydroxy-3-(2,3-difluorophenyl)-1,2-benzisoxazole in 120 ml of DMF, 6.36 g of K2CO3 is added followed by 7.83 g of BrCH2CO2C2H5. The reaction is warmed at 60° C. for two hours and then allowed to stand for 18 hours. To the mixture 200 ml of water and 15 ml of 50% NaOH are added. The mixture is warmed at 90° C. for 90 minutes, poured into water and acidified. The product is extracted into ethylacetate which is dried over Na2SO4 and evaporated to give {[7-chloro-3-(2,3-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid, mp 183°-187° C.

Provenance & Evidence