HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2-Chloro-1,3-dimethoxybenzene | HCID 13015717 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 3-Chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone | HCID 13015718 | — |
Reaction Steps
2-chlororesorcinol dimethyl ether (22.0 g) and o-fluorobenzoyl chloride (20.2 g) are dissolved in 250 ml of dichloroethane, chilled in an ice bath and treated with AlCl3 (18.6 g). Fifteen minutes after the addition is complete, the reaction is heated to reflux for 30 minutes. It is poured into H2O and extracted with ethylacetate. Evaporation and trituration with hexane gives 3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone, mp 132°-133° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-e22f11222ac44074a7fb3bca009e012a |
| Source note | uspto-grants-1988_03 |