HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → [(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2-fluorophenyl)methylidene]amino] acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-chloro-6-[(E)-C-(2-fluorophenyl)-N-hydroxycarbonimidoyl]-3-methoxyphenol | HCID 136477409 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | [(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2-fluorophenyl)methylidene]amino] acetate | HCID 136477412 | — |
Reaction Steps
E-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone oxime (18.1 g) is warmed at 60° C. for 30 minutes with 9 ml of acetic anhydride. The reaction mixture is distributed between ether and 10% NaHCO3 and washed with 10% NaHCO3 until the washes remained basic. Drying, evaporation and trituration with hexane gives E-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime, mp 125°-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-3d47532432f24e5bb30b06e67acd657e |
| Source note | uspto-grants-1988_03 |